Wednesday September 22nd

 Arrival in the afternoon. 

 Registration opened at 17:30

18:35 Opening of the workshop
  Organizing committee
18:40 - 18:50


Presentation of the "Tumour targeting, Imaging, Radiotherapies network" of the Cancéropôle Grand Ouest

  Dimitris Visvikis, LaTIM, National Institute of Health & Clinical Sciences,  Brest, France.


18:50 - 19:05







Sponsors communications


Katarzyna Desrocques, MOLECUBES, Ghent, Belgium.


Stéphane Supiot, La Fondation ARC pour la Recherche sur le Cancer, France.

19:05 - 20:00


"Clinical challenges and opportunities to reverse adaptation of the tumour and its ecosystem to radiotherapies"




Invited speaker: Irene Virgolini, Department of Nuclear Medicine, Medical University of Innsbruck, Austria.

20:15 Dinner

Thursday September 23rd

Session 1: Tumour adaptation to radiotherapies: biological aspects

8:30 - 9:00

“Getting Warburg to be right to improve radiotherapy efficacy”


Invited speaker: Olivier Feron, Cancer Translational Research Lab, Pole of Pharmacology and Therapeutics, Institute of experimental and clinical research, UCLouvain, Belgium.


9:00 - 10:20

4 selected talks
  “Dissect the tumor microenvironment to battle cancer radioresistance and immune escape“
Ana Canha-Borges, Institute of Investigation and Innovation in Health, University of Porto, Portugal.
  “Regulatory functions of cancer associated fibroblasts following radiation”
Kristin Lode, Faculty of Health Sciences. UiT – The arctic University of Norway, Tromsø, Norway.
  In-vitro microvasculature-on-a-chip to study biological alterations due to radiotherapy”
Luca Possenti, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  “Voluntary wheel running does not enhance radiotherapy efficiency in a preclinical model of prostate cancer: the importance of physical activity modalities?”
Cindy Richard, M2S, University of Rennes, France.
10:20 - 10:50 Poster session & Coffee break

10:50 - 11:50

3 selected talks

  “Overcoming hypoxia-induced radioresistance of glioblastoma cells by hadrontherapy”
Nolwenn Pasquet, Normandie Univ, UNICAEN, CEA, CNRS, ISTCT / CERVOxy group, GIP Cyceron, Caen, France.
  “Determination of genes implicated in the resistance to proton beam therapy during the treatment of glioblastoma”
Jia-Wei Chen, Namur Research Institute for Life Sciences (NARILIS), University of Namur, Belgium.
  “Assessment of cellular response to internal radiotherapy delivered by Auger-electrons emissions“
Radu Marian Serban, Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH, Magurele-Ilfov, Romania.

11:50 - 12:00


Sponsors communications



Adam BadarMILabs, Utrecht, The Netherlands.


  NEXT IRC Transformed & Arronax cyclotron, Nantes, France.
12:15 Lunch

Session 2 : Tumour adaptation to radiotherapies: contribution of imaging

14:00 - 14:30 “Hypoxia imaging and tumour adaptation to radiotherapies”
  Invited speaker: Heidi Lyng, Oslo University Hospital, The Norwegian Radium Hospital, Department of Radiation Biology, Oslo, Norway.

14:30 - 15:30

3 selected talks
  “A portable gamma camera for the optimization of the patient dosimetry in radioiodine therapy of thyroid diseases”
Théo Bossis, University of Paris-Saclay, CNRS/IN2P3, IJCLab, Orsay, France.
  In vitro and in vivo evaluation of a 64Cu-radiolabelled anti-CD 138 antibody for Multiple Myeloma imaging and dosimetry”
Cassandra Métivier, CHU Nantes, CNRS, Inserm, CRCINA, University of Nantes, France.
  “Longitudinal and multiparametric study of radiotherapy toxicities on healthy brain in the rat”
Fatima-Azzahra Dwiri, Normandie Univ, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP Cyceron, Caen, France.
15:30 - 16:00 Coffee break
16:00 - 17:00 3 selected talks
  “Characterization of hypoxia in brain metastases from lung cancer: from the pre-clinical approach to the clinic“
Jade Fantin, Normandie Univ, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP Cyceron, Caen, France.
  “Apparent diffusion coefficient and high b-value Diffusion-Weighted Magnetic Resonance Imaging as biomarkers for tumor response to re-irradiation with Carbon Ion Radiation Therapy for pelvic rectal recurrences: an explorative analysis”
Giula Fontana, National Center for Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.
  “Quantitative Magnetic Resonance Imaging during prostate radiotherapy treatment: preliminary study using a 0.35T MR-linac system”
Louis Marage, Centre Georges-François Leclerc, Dijon, France.
  99mTc-Tektrotyd, the first radiopharmaceutical for NETs diagnosis at the Nuclear Medicine Service in Kosovo”
Armend Jashari, Alma Mater Europaea Campus College "REZONANCA", Prishtine, Republic of Kosovo.
17:20 - 17:30 sponsor communication
  ILIAD SIRIC, Michel Chérel, Nantes, France.
19:00 Dinner

Friday September 24th

Session 3 : Innovative radiation therapeutic strategies

8:30 - 9:00


"Irradiation at ultra high dose rate: from the FLASH effect to clinical translation"  

Invited speaker: Marie-Catherine Vozenin, Department of Radiation Oncology, Department of Oncology, Lausanne University Hospital and Lausanne University, Switzerland



9:00 - 10:20

4 selected talks

  “Adaptation of DNA damage repair using DNA-PKcs inhibitors as selective potentiation of peptide receptor radionuclide therapy“
Thom Reuvers, Department of Radiology & Nuclear Medicine, Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.
  “CAIX-targeted radionuclide therapy in immunodeficient and immunocompetent mouse models”
Simone Kleinendorst, Department of Medical Imaging: Nuclear Medicine, Radboudumc, Nijmegen, The Netherlands.
  “Anti-HER2 2Rs15d nanobody labeled with 225Ac as a potential molecule for targeted alpha therapy“
Magdalena Rodak, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.
  “From Ouzo effect to combined chemo-radio-therapies“
Déborah Iglicki, Institut des Sciences Chimiques de Rennes - UMR6226 CNRS, University of Rennes, France.
10:20 - 10:50 Poster session & Coffee break  

10:50 - 12:30

5 selected talks

  “Improving systemic radiotherapy with radioenhancing nanoparticles”
Marine Le Goas, Faculté de Pharmacie, Université de Montréal, Québec, Canada.
  “Novel therapeutic combination strategies in non-BRAF mutant melanoma“
Malak Sabbah, Laboratory of Oncology and Experimental Surgery, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
  “Investigating the interest of proton therapy to obtund radiation-induced lymphopenia in a context of brain tumour irradiation: a preclinical study“
Julie Coupey, Normandie Univ, UNICAEN, CEA, CNRS, ISTCT/CERVOxy group, GIP CYCERON, Caen, France.
  In silico feasibility study of carbon ion radiotherapy with simultaneous integrated boost (CIRT-SIB) for head and neck adenoid cystic carcinoma“
Edoardo Mastella, CNAO, National Center for Oncological Hadrontherapy, Pavia, Italy.
  “Trastuzumab radioimmunoconjugates – promising strategy for selective anticancer therapy“
Paulina Apostolova, Faculty of medical sciences, Goce Delcev University, Stip, Republic of North Macedonia.
12:30 Lunch  

Session 4 : Learning and data driven techniques

14:00 - 14:30


“Radiomics for immune response characterization under RT treatment”  

Invited speaker: Charlotte Robert, Molecular radiotherapy unit, Inserm, Gustave Roussy, University of Paris –Sud, France.



14:30 - 15:30

3 selected talks of young researchers

  “A mathematical model of the low-grade gliomas response to chemotherapy and radiotherapy: Therapeutic implications“
Luis E. Ayala-Hernández, Departamento de Ciencias Exactas y Tecnología Centro Universitario de los Lagos, Universidad de Guadalajara, Jalisco, Mexico.
  “Radiation necrosis vs progression in Brain Metastases treated with stereotactic radiosurgery: How to distinguish them using mechanistic mathematical models”
Beatriz Ocaña-Tienda, Mathematical Oncology Laboratory (MOLAB), Instituto de Matemática Aplicada a la Ciencia y la Ingeniería, Universidad de Castilla-La Mancha, Ciudad Real, Spain.
  “Spatial analysis of preclinical dynamic contrast-enhanced ultrasound (DCE-US) images for assessment of tumour response to radiotherapy”
Dana Naser Tahboub, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom.
15:30 - 16:00 Poster session & Coffee break  

16:00 - 17:00

3 selected talks of young researchers

  “Development and prospective validation of a spatial dose pattern based model predicting acute pulmonary toxicity in patients treated with volumetric arc-therapy for locally advanced lung cancer“
Vincent Bourbonne, LaTIM UMR 1101 INSERM & Department of Radiation Oncology, University Hospital, Brest, France.
  “Synthetic tumor insertion using one-shot generative learning for cross-modal image segmentation”
Guillaume Sallé, UMR 1101 Inserm LaTIM, UBO, IMT Atlantique & CHRU, Brest, France.
  “Patient-specific 4DCT respiratory motion synthesis using generative adversarial networks”
Yi-heng Cao, UMR 1101 Inserm LaTIM, UBO, IMT Atlantique & CHRU, Brest, France.
17:00 Social event  

Saturday September 25th

Session 5 : Futures challenges


9:00 -9:30  


"Radiobiology of targeted radionuclide therapy: necessity and current challenges"
  Julie Nonnekens, Dept. of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

9:30 -10:00 


"Data science and machine learning in radiomics: past, present, perspectives"
  Mathieu Hatt, LaTIM, National Institute of Health & Clinical Sciences, University of Brest, France.
10:00-10-15 Coffee break
10:15-11:00 Round table on industrial point of view




Focus on European policy in Oncology and elaboration of call of projects


11:45-12:00 Awards
12:00 Lunch
13:10 End of the workshop - Departure

Other informations

Scientific sessions:

- Duration of selected talks is 15 minutes and 5 minutes for questions.


Poster session:

- The format of poster is A0.

- Discussion around the posters will be possible during all coffee breaks. Posters should therefore be hanged for the entire duration of the workshop.