Program
Wednesday October 5th
Arrival in the afternoon. Registration opened at 18:00
19:00 Opening of the Workshop:
Organizing
committee
19:05 Presentation of the « Tumor Targeting & Radiotherapies network » of the Canceropôle Grand Ouest
Michel Chérel, CRCI2NA, National Institute of Health & Clinical Sciences, Nantes, France.
19:10 Sponsor communication
Loig Vaugier, ICO, Saint-Herblain, France.
Presentation of the "Société Française du Cancer".
19:15 Plenary conference : Jean-Emmanuel Bibault, Professor, Department of Radiation Oncology, Hôpital Européen Georges Pompidou, Paris, France.
“Applications of Artificial Intelligence in Oncology”
20:30 Dinner
Thursday October 6th
Session 1: New tools for imaging and external beam radiotherapy
Chairmen:
Loig Vaugier, Grégory Delpon
8:30 – 9:00 Invited lecture: Kuangyu Shi, Associate Professor, Head of Lab for Artificial
Intelligence and Translational Theranostics, Dept. Nuclear Medicine, University of
Bern, Switzerland.
“Total body PET imaging: Methodological challenges and clinical opportunities”
9:00 – 10:00 Adrien Hourlier, Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg
France.
“Novel Positron Emission
Tomography with Opaque Liquid Scintillator Detection
Technology”
Venkata Sai Sundar
Kandarpa, LaTIM, INSERM, UMR 1101, Université de
Bretagne Occidentale
Brest, France.
“C-DenseNet: A direct
neural network-based approach for Total Body PET Image
Reconstruction”
Marcelina Abal-Sanisidro, Nano-Oncology and Translational Therapeutics Unit,
Health Research Institute of Santiago de Compostela (IDIS), Santiago de
Compostela,
Spain.
“Bioluminescence
Biodegradable Sphingomyelin Nanosystems (SNs) for protein
delivery for in vitro and in vivo tracking”
10:00 – 10:30 Poster session & Coffee break
10:30 - 11:00 Invited lecture: Iuliana Toma-Dasu, Professor in Medical Radiation Physics, Head
of Medical Radiation Physics Division, Stockholm University and Karolinska
Institutet, Cancer Center Karolinska, Karolinska University Hospital Solna,
Stockholm,
Sweden.
“Adaptive radiotherapy
based on tumour responsiveness”
11:00 – 12:00 Francesca Di Franco, Léon Bérard Cancer Center, Université de Lyon & CREATIS,
INSA, Université
de Lyon, CNRS UMR5220, Inserm U1044, Lyon, France.
“Dosimetric impact
of real-time motion and daily anatomical changes during
ultra-
hypofractionated prostate cancer radiotherapy”
Maria Pedrosa Rivera, University of Grenoble Alpes, CNRS, Grenoble INP,
LPSC-IN2P3, Grenoble,
France.
“In vitro
irradiations and biophysical modelling for dosimetry in Boron Neutron
Capture
Therapy”
Gaëlle
Saade, Nantes University, CNRS, US2B, UMR 6286 & Institut de
Cancérologie de l’Ouest Nantes, France.
“Reduction of
radiotoxicity by ultra-high dose rate protontherapy”
12:00 - 12:20 Sponsor communications
Jacques Barbet, GIP Arronax, Nantes, France.
“The innovation potential of the TransForMed cluster for the development
of nuclear medicine.”
Michel Chérel, SIRIC ILIAD, Nantes, France.
12:30 Lunch
Session 2: Molecules and contrast agents
Chairwomen: Sara Lacerda, Maryline Beyler
14:00 – 14:30 Invited lecture: Kristina Djanashvili, Associate Professor, Delft University of
Technology, The
Netherlands.
“Plug-and-play principle in design of metal-based theranostic probes”
14:30 – 15:30 Lucie Arnaud, Université Clermont Auvergne, Inserm, Imagerie Moléculaire et
Stratégies Théranostiques, UMR
1240, Clermont-Ferrand, France.
“SPECT or PET Imaging of mIDH1
Mutant Cancers with Novel Radiohalogenated
Analogues of
Olutasidenib”
Hanadi Nahas,
Institut NUMECAN (Nutrition Metabolisms and Cancer), Inserm
UMR-S 1241, INRAE UMR-A 1341,
University of Rennes, France.
“Study of radiolabeled
hepatotropic peptide derivatives for the diagnosis and
treatment of
hepatocellular carcinoma”
Carolina Gobbi,
Institute of Condensed Matter Chemistry and Technologies for
Energy ICMATE-CNR, Padova,
Italy.
“Impact of different
[99mTc][Tc(N)PNP]-synthons on the labeling and
pharmacokinetics of the small c-RGDfK peptide”
15:30 – 16:00 Coffee break
16:00 – 17:20 Tircsó Gyula,
Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Hungary.
“Design of bifunctional PC2A-derivative ligands for 52Mn-based PET detection of HER+ breast cancer tumors using affybody vector molecules”
Marie Hautiere, Université Paris-Saclay, CEA, DMTS, SPI, LENIT, Gif-sur-Yvette, France & Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay,
France.
“Preclinical evaluation of novel 89Zr-labelled immunoPET tracer targeting the endothelin A receptor in glioblastoma patient-derived orthotopic xenograft model”
Marie Le Roy, UMR CNRS 6521 CEMCA, University of Brest, France.
“Tracking CXCR4 with a small synthetic organic vector: chelator conjugation, 64Cu radiolabeling and in vivo targeted-PET imaging”
Florent Magot, Université Clermont Auvergne, Inserm, Imagerie Moléculaire et Stratégies Théranostiques, UMR 1240, Clermont-Ferrand, France.
“In vivo TEP imaging of chondrosarcoma”
19:00 Dinner
Friday October 7th
Session 3: The use of alpha particles
Chairmen: Michel Chérel, Jean-François Gestin
8:45 - 9:15
Invited lecture: Nicolas Chouin, Associate Professor & Romain
Eychenne, Researcher, Nuclear Oncology team, CRCI2NA, Center for Integrated Research in Cancer and Immunology, Nantes, France.
"Targeted alpha therapy, from radiobiological aspects to potential applications"
9:15 - 10:15 Jonathan Tranel, Department of Radiology and Biomedical Imaging, University of
California San Francisco, San
Francisco CA, United States of America.
“Deposited energy microdistribution of
177Lu and 225Ac in a model of cancer
associated
fibroblasts“
Victor Levrague, LPSC,
Université Grenoble Alpes, Grenoble, France.
“Impact of intracellular
radionuclide distribution in Targeted Alpha Therapy : a
Monte-Carlo biophysical study in 3D multicellular model“
Alexis Doudard,
Grand Accélérateur National d’Ions Lourds (GANIL), CEA/DRF
CNRS/IN2P3, Caen,
France.
“In vitro
dosimetry for assessment of Targeted-Alpha-Therapy“
10:15 – 10:45 Poster session & Coffee break
10:45 - 11:45 Charlotte Jacquet, CRCI2NA, UMR 1307 CNRS 6075 NU, Nantes, France.
“Radiobiology of alpha emitters: development of an in vitro tumor model of targeted alpha-therapy“
Nina Laurent, CRCI2NA, UMR 1307 CNRS 6075 NU, Nantes, France.
“Targeting of circulating tumor cells in triple negative breast cancer“
Loris Roncali, Université d’Angers, Inserm U1307, CNRS U6075, Nantes Université, CRCI2NA, Angers, France.
“Locoregional Astatine-211 Radioimmunotherapy Targeting Syndecan-1 in a Syngeneic Glioblastoma Mouse Model”
12:00 Lunch
Session 4: Theranostic aspects
Chairwoman and chairman: Latifa Rbah-Vidal, Nicolas Lepareur
13:30 - 14:00 Invited lecture: Gilbert Fruhwirth, Senior lecturer in imaging biology, group leader
“Imaging therapies and cancer”, Comprehensive Cancer Centre at King’s College,
London, United Kingdom.
"Theranostics - A driver of
Personalized Medicine"
14:00 - 15:00 Alexandre Lugat, Medical Oncology Department, CHU Nantes & Nantes Université,
Université d'Angers, CHU Nantes, INSERM, CNRS, CRCI2NA, Nantes, France.
“Evaluation of peptide receptor radionuclide therapy using 225Ac-DOTATOC in a
mouse model of liver
metastases of pancreatic neuroendocrine tumor“
Eva-Alexandra
Salvanou, Institute of Nuclear & Radiological Sciences & Technology,
Energy & Safety, National Center for Scientific Research “Demokritos”, Athens &
Department of Pharmacy, School
of Health Sciences, University of Patras, Greece.
“Radiolabeled Magnetic
Nanoparticles for Cancer Theranostics“
Ivan Hawala,
Department of Imaging Chemistry & Biology, School of Biomedical
Engineering &
Imaging Sciences, King’s College London, United Kingdom.
“Bn2-DT3A: a novel
linear trifunctional chelator for the development of
molecular
imaging probes for theranostic purposes“
15:00 - 15:15 Coffee break
15:15 – 16:15 Fateme Madani, Department of Medical Nanotechnology, School of Advanced
Technologies in
Medicine, Tehran University of Medical Sciences, Tehran, Iran.
“Novel targeted
chemotherapy using surface-modified polymeric nanoparticles
for the
treatment of glioblastoma multiforme”
Ines Melo E
Costa, Department of Imaging Chemistry and Biology, School of
Biomedical Engineering and Imaging Sciences, King’s College London, London,
United
Kingdom.
“Correlation of
radiotoxicity induced by Auger electron emitters and Beta minus
particles
with delivered absorbed dose”
Catarina I. G.
Pinto, C2TN – Centro de Ciências e Tecnologias Nucleares, Instituto
Superior Técnico,
Universidade de Lisboa, Portugal.
“64CuCl2 – a promising
tool for prostate and brain cancer theranostics“
16:30 Social event
Saturday October 8th
Session 5: Vectors for
innovative combination therapies
Chairman: Emmanuel Garcion
9:00 - 9:30 Invited lecture: Prisca Boisguerin, Senior researcher, Development of visceral
smoothmuscle and associated pathologies team, PhyMedExp, Montpellier, France.
"Highway to cancer: WRAP-based
nanoparticles for siRNA delivery"
9:30 - 10:30 Pedro Cruz Nova, Departamento de materiales radiactivos, Instituto Nacional de
Investigaciones Nucleares, Carretera México-Toluca S/N, Ocoyoacac, Mexico.
“Chemo-radiotherapy with 177Lu-DOTA-PLGA(RGF)-CXCR4L system for the targeted treatment of colorectal cancer”
Kamil Wawrowicz, Institute of Nuclear Chemistry and Technology, Warsaw, Poland.
“Radiobioconjugates of 193m,195mPt nanoparticles for combined „chemo-Auger electron” therapy of hepatocellular carcinoma (HCC) and HER2+ breast and ovarian cancers“
Kinga Żelechowska-Matysiak, Institute of Nuclear Chemistry and Technology, Warsaw,
Poland.
“Multimodal radiobioconjugate - DOX-PEG-198AuNPs-PEG-Tmab for targeted radionuclide therapy of HER2-positive cancers“
10:30 – 10:50 Coffee Break
10:50 - 11:50 Rosa Bellavita, University of Naples “Federico II”, Department of Pharmacy,
Naples, Italy.
“Smart self-assembled
peptides-based nanofibers for targeted drug delivery in
triple-negative breast cancer”
Amel Djoudi, CRCI2NA,
INSERM, Université de Nantes, Université d’Angers, Angers,
France.
“Development of innovative
nanocomposite hydrogels for the locoregional
treatment of Glioblastoma Multiforme”
Rodolfo Molina-Pena,
Université d’Angers, Université de Nantes, Inserm, CRCI2NA,
SFR ICAT, Angers, France.
“Silk-fibroin interventional
nano-trap for the treatment of glioblastoma:
translation of an ecological trap in cancer therapy”
12:00 Lunch
13:30 End of the workshop – Departure