Program
Wednesday October 4th
Arrival in the afternoon.
Registration opened at 18:00
19:00 | Opening of the workshop |
Organizing committee | |
19:05 - 19:10 |
Presentation of the "Tumour targeting, Imaging, Radiotherapies network" of the Cancéropôle Grand Ouest |
Dimitris Visvikis, Research Director, LaTIM, National Institute of Health & Clinical Sciences, Brest, France.
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19:10 - 19:20
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Sponsor communications
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19:20 - 20:15 |
Plenary conference: |
Jason P. Holland, Associate Professor, Department of Chemistry, University of Zürich, Switzerland. |
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“New tactics in the design of radiotheranostics”
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20:30 | Dinner |
Thursday October 5th
Session 1: How to distribute the dose in radiotherapies in time and space?
8:30 - 9:00
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Invited speaker: Eric Deutsch, Professor, Department of Oncology and Radiotherapy, Institut Gustave Roussy, Paris, France. |
"Dose distribution, rate and volumes in radiotherapy, preclinical data and new concepts" |
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9:00 - 10:00 |
3 selected talks |
Valentin Beaufils, Université de Caen-Normandie, CNRS, Normandie Univ, ISTCT UMR6030, GIP Cyceron, Caen, France. “Optimisation study of a whole-brain irradiation model in the rat: comparison between vertical and horizontal X-ray beams” |
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Gaël Simonin, Institut Pluridisciplinaire Hubert Curien, UMR 7178, Strasbourg, France. “Towards FLASH dosimetry on PRECy platform” |
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Gautier Daviau, Grand accélérateur National d'Ions Lourds (GANIL), CEA/DRF-CNRS/IN2P3, Boulevard Henri Becquerel, Caen, France. “Development of a new high spatial and temporal resolution scintillating dosimeter“ |
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10:00 - 10:30 | Poster session & Coffee break |
10:30 - 11:30 |
3 selected talks |
Elisabeth Bodenstein, OncoRay, National Center for Radiation Research in Oncology- Faculty of Medicine and University, Hospital Carl Gustav Carus- Technische
Universitat Dresden-Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany. “Proton radiography used for high precision small animal irradiation at ultra-high dose rates“ |
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Manon Evin, Nantes Université, IMT Atlantique, CNRS/IN2P3, SUBATECH, Nantes, France. “Dosimetric environment and first results of the studies on the physicochemical and biological mechanisms of FLASH hadrontherapy at the ARRONAX cyclotron” |
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Eva Bogaerts, Department of Oncology, KU Leuven, Leuven & Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain,
Woluwé-Saint-Lambert, Belgium. “Proton irradiation at ultra-high-dose-rate results in lower induction of radiation-responsive genes in zebrafish embryos” |
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11:30 - 12:00
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Sponsor communications
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12:15 | Lunch |
Session 2: New paradigms in tumour targeting and imaging
14:00 - 14:30
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Invited speaker: Marcel Hollenstein, Research Scientist, Institut Pasteur, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, CNRS UMR3523, Paris, France. |
“Nucleic acids as tools for the treatment and diagnostics of cancer” | |
14:30 - 15:30 |
3 selected talks |
Natalia Helen Ferreira, Nantes - Angers Cancer and Immunology Research Center, University of Angers, SFR ICAT, Angers, France. "Implantable silk-fibroin hyaluronic-acid scaffold into resection cavities: Modifying Glioblastoma Ecosystem Dynamics to Enhance Efficacy of Radiotherapy" |
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Nina Laurent, CRCI2NA, UMR 1307 CNRS 6075 NU, Nantes, France. “Overview of Circulating Tumor Cells heterogeneity for Targeted Alpha Therapy“ |
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Liliana Santos, CIBIT/ICNAS – Institute for Nuclear Sciences Applied to Health, University of Coimbra, Portugal. “Therapeutic Efficacy of [177Lu]Lu-DOTA-Trastuzumab in Trastuzumab-resistant HER2-Positive metastatic lesions” |
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15:30 - 16:00 | Coffee break |
16:00 - 17:00 | 4 selected talks |
Joana F. Santos, C2TN Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, U. Lisboa, Portugal. “Dual-targeted 111In- and 161Tb-Radiocomplexes for Prostate Cancer Theranostics“ |
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Jonas Genz, University of Zurich, Zurich, Switzerland. “Matched Pair Theranostics with 99mTc and 188Re-DETA-N-Onartuzumab for the Hepatocyte Growth Factor Receptor“ |
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Matteo Mari, Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy. “Coumarin derivatives for MCT1 targeting in nuclear medicine: from fluorine to copper“ |
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Lucas Petitpoisson, Equipe de Synthèse pour l’Analyse, Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France. “Tb(III) octadentate bispidine-based complexes for potential application in radiotherapy and theragnostic imaging” |
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19:00 | Dinner |
Friday October 6th
Continued Session 2: New paradigms in tumour targeting and imaging
8:20 - 10:00 |
5 selected talks | |
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Océane Baffroy, Institut de Chimie Moléculaire de l’Université de Bourgogne, ICMUB CNRS, UMR 6302, Université de Bourgogne, Dijon, France. |
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Amélie Godard, Institut de Chimie Moléculaire de l’Université de Bourgogne, ICMUB CNRS, UMR 6302, Université de Bourgogne, Dijon, France. |
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Federica Battistin, Department of Chemistry, University of Zurich, Zurich, Switzerland. |
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Tibor Csupász, University of Debrecen, Faculty of Science and Technology, Institute of Chemistry - Department of Physical Chemistry, Debrecen,
Hungary. |
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Alexandra Loubières, Laboratoire CEMCA UMR CNRS 6521, Brest, France. |
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10:00 - 10:30 |
Poster session & Coffee break |
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Session 3: Alternative biological models
10:30 - 11:00
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Invited speaker: Rob Coppes, Professor, Department of Biomedical Sciences of Cells & Systems & Department of Radiation Oncology, University Medical Center Groningen & University of Groningen, Groningen, the Netherlands. | |
“The use of organoids in radiotherapy research; mechanisms, prediction and regeneration” |
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11:00 - 12:00 |
3 selected talks |
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Maxime Dubail, Institut Curie, Inserm U1021-CNRS UMR 3347, University Paris-Saclay, PSL Research University, Centre Universitaire, Orsay,
France. “Development of an ex vivo assay enabling rapid quantification of radiotherapy induced toxicities in healthy lung“ |
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Estrella Passerat de la Chapelle, Space Biosciences Division, NASA Ames Research Center & Blue Marble Space Institute of Science & Nantes University, Nantes,
France. “Neurovascular responses to ionizing radiation in a human organ-on-a-chip model” |
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Mathieu Chocry, ICO & Nantes Université, CNRS, US2B, UMR 6286, DNA-repair Group, Nantes, France. “Induced radioresistance following communication of pericytes and vascular endothelial cells with glioblastoma cancer cells“ |
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12:00 - 14:00 | Lunch |
Session 4: Artificial intelligence and Modeling
14:00 - 14:30
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Invited speaker: Julien Bert, Research scientist, LaTIM, National Institute of Health & Clinical Sciences, Brest University,
France. “AI dose calculation: application in radiation and radionuclide therapies” |
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14:30 - 15:50 |
4 selected talks |
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Marc Ryhiner, Department of Nuclear Medicine, Inselspital, University of Bern, Switzerland. “Simulating quantitative PARPi radiosensitization of BRCA deficient cancer cells during radiopharmaceutical therapies” |
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Eduardo Rios Sanchez, Creatis, Lyon & Siemens Healthcare SAS, Paris, France. “68Ga-PSMA PET/CT Imaging Features with PSA Variation for Castration-Resistant Prostate Cancer Patients“ |
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Katerine Viviana Diaz Hernandez, Science Faculty, University of Zürich, Zürich, Switzerland. “Fitting of novel analytical population tumor control probability model to NSCLC data“ |
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Paul Giraud, Radiation Oncology, Hôpital Pitié-Salpêtrière, Paris, France. “External validation of a predictive model for severe malnutrition trained on a multicentric real-life cohort from UNITRAD” |
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15:30 - 16:10 | Poster session & coffee break | |
16:30 | Social event |
Saturday October 7th
Session 5: Therapeutic combinations
9:00 - 9:30
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Invited speaker: Anna Mondino, Research scientist, Head of Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases,
IRCCS San Raffaele Scientific Institute, Milan, Italy. |
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9:30 - 10:30 |
3 selected talks |
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Charlotte Jacquet, CRCI2NA, UMR 1307 CNRS 6075 NU, Nantes, France. “Radiobiology of alpha-particles: Immunogenicity of anti-tumor targeted-alpha therapy in mouse models“ |
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Hannah Bargh-Dawson, Institute of Cancer Research, London, United Kingdom. “Evaluation of murine head and neck carcinoma models for determining response to ultrasound-stimulated microbubbles combined with radiotherapy” |
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Juan Jiménez-Sánchez, Mathematical Oncology Laboratory (MOLAB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain. “Chemo-radiotherapy optimization in gliomas: discrete models and virtual clinical trials“ |
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10:30 - 10:50 | Coffee break | |
10:50 - 11:50 |
3 selected talks | |
Arianna Rinaldi, Nantes - Angers Cancer and Immunology Research Center, University of Angers, SFR ICAT, Angers, France. “Polymer-lipid Hybrid Nanomedicines for siRNA Delivery Against Glioblastoma” |
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Fábio A. C. Lopes, Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Braga, Portugal. “Development of multifunctional liposomes containing magnetic/gold nanoparticles for combination cancer therapies” |
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Sarah Stelse-Masson, Institute for Advanced Biosciences, INSERM, CNRS & Synchrotron Radiation for Biomedicine, Université Grenoble Alpes, Grenoble,
France. “Scintillating nanoparticles to induce radiation dose-enhancement and X-PDT for pancreatic cancer” |
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12:00 | Lunch & awards | |
13:15 | End of the workshop - Departure |
Other informations
Scientific sessions:
- Duration of selected talks is 15 minutes and 5 minutes for questions.
Poster session:
- The format of poster is A0 (vertical).
- Discussion around the posters will be possible during all coffee breaks. Posters should therefore be hanged for the entire duration of the workshop.