Wednesday October 4th

 Arrival in the afternoon. 

 Registration opened at 18:00

19:00 Opening of the workshop
  Organizing committee
19:05 - 19:10


Presentation of the "Tumour targeting, Imaging, Radiotherapies network" of the Cancéropôle Grand Ouest


Dimitris Visvikis, Research Director, LaTIM, National Institute of Health & Clinical Sciences,  Brest, France.


19:10 - 19:20


Sponsor communications


19:20 - 20:15

Plenary conference:


Jason P. Holland, Associate Professor, Department of Chemistry, University of Zürich, Switzerland.


“New tactics in the design of radiotheranostics”


20:30 Dinner

Thursday October 5th

Session 1: How to distribute the dose in radiotherapies in time and space?

8:30 - 9:00


Invited speaker: Eric Deutsch, Professor, Department of Oncology and Radiotherapy, Institut Gustave Roussy, Paris, France.

"Dose distribution, rate and volumes in radiotherapy, preclinical data and new concepts"


9:00 - 10:00

3 selected talks
  Valentin Beaufils, Université de Caen-Normandie, CNRS, Normandie Univ, ISTCT UMR6030, GIP Cyceron, Caen, France.
“Optimisation study of a whole-brain irradiation model in the rat: comparison between vertical and horizontal X-ray beams”
  Gaël Simonin, Institut Pluridisciplinaire Hubert Curien, UMR 7178, Strasbourg, France.
“Towards FLASH dosimetry on PRECy platform”
  Gautier Daviau, Grand accélérateur National d'Ions Lourds (GANIL), CEA/DRF-CNRS/IN2P3, Boulevard Henri Becquerel, Caen, France.
“Development of a new high spatial and temporal resolution scintillating dosimeter“
10:00 - 10:30 Poster session & Coffee break

10:30 - 11:30

3 selected talks

  Elisabeth Bodenstein, OncoRay, National Center for Radiation Research in Oncology- Faculty of Medicine and University, Hospital Carl Gustav Carus- Technische Universitat Dresden-Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.
“Proton radiography used for high precision small animal irradiation at ultra-high dose rates“
  Manon Evin, Nantes Université, IMT Atlantique, CNRS/IN2P3, SUBATECH, Nantes, France.
“Dosimetric environment and first results of the studies on the physicochemical and biological mechanisms of FLASH hadrontherapy at the ARRONAX cyclotron”
  Eva Bogaerts, Department of Oncology, KU Leuven, Leuven & Institut de Recherche Expérimentale et Clinique (IREC), Université catholique de Louvain, Woluwé-Saint-Lambert, Belgium.
“Proton irradiation at ultra-high-dose-rate results in lower induction of radiation-responsive genes in zebrafish embryos”

11:30 - 12:00


Sponsor communications


12:15 Lunch

Session 2: New paradigms in tumour targeting and imaging

14:00 - 14:30



Invited speaker: Marcel Hollenstein, Research Scientist, Institut Pasteur, Department of Structural Biology and Chemistry, Laboratory for Bioorganic Chemistry of Nucleic Acids, CNRS UMR3523, Paris, France.
  “Nucleic acids as tools for the treatment and diagnostics of cancer”

14:30 - 15:30

3 selected talks
  Natalia Helen Ferreira, Nantes - Angers Cancer and Immunology Research Center, University of Angers, SFR ICAT, Angers, France.
"Implantable silk-fibroin hyaluronic-acid scaffold into resection cavities: Modifying Glioblastoma Ecosystem Dynamics to Enhance Efficacy of Radiotherapy"
  Nina Laurent, CRCI2NA, UMR 1307 CNRS 6075 NU, Nantes, France.
“Overview of Circulating Tumor Cells heterogeneity for Targeted Alpha Therapy“
  Liliana Santos, CIBIT/ICNAS – Institute for Nuclear Sciences Applied to Health, University of Coimbra, Portugal.
“Therapeutic Efficacy of [177Lu]Lu-DOTA-Trastuzumab in Trastuzumab-resistant HER2-Positive  metastatic lesions”
15:30 - 16:00 Coffee break
16:00 - 17:00 4 selected talks
  Joana F. Santos, C2TN Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, U. Lisboa, Portugal.
“Dual-targeted 111In- and 161Tb-Radiocomplexes for Prostate Cancer Theranostics“
  Jonas Genz, University of Zurich, Zurich, Switzerland.
“Matched Pair Theranostics with 99mTc and 188Re-DETA-N-Onartuzumab for the Hepatocyte Growth Factor Receptor“
  Matteo Mari, Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy.
“Coumarin derivatives for MCT1 targeting in nuclear medicine: from fluorine to copper“
  Lucas Petitpoisson, Equipe de Synthèse pour l’Analyse, Université de Strasbourg, CNRS, IPHC UMR 7178, Strasbourg, France.
“Tb(III) octadentate bispidine-based complexes for potential application in radiotherapy and theragnostic imaging”
19:00 Dinner

Friday October 6th

Continued Session 2: New paradigms in tumour targeting and imaging

8:20 - 10:00

5 selected talks  



Océane Baffroy, Institut de Chimie Moléculaire de l’Université de Bourgogne, ICMUB CNRS, UMR 6302, Université de Bourgogne, Dijon, France.
“Toward water-soluble gold-based Aza-BODIPY Theranostic“


Amélie Godard, Institut de Chimie Moléculaire de l’Université de Bourgogne, ICMUB CNRS, UMR 6302, Université de Bourgogne, Dijon, France.
“NIR-II aza-BODIPYs, a new family of contrast agents for fluorescence-guided surgery of cancers”


Federica Battistin, Department of Chemistry, University of Zurich, Zurich, Switzerland.
“99mTc(η6-pharm)2]+ synthesis with direct labelling of pharmaceuticals in water”


Tibor Csupász, University of Debrecen, Faculty of Science and Technology, Institute of Chemistry - Department of Physical Chemistry, Debrecen, Hungary.
“Synthesis and characterization of hypoxia-sensitive 44Sc(III) and 52Mn(II) macrocyclic complexes for their application in PET imaging“


Alexandra Loubières, Laboratoire CEMCA UMR CNRS 6521, Brest, France.
“Zr(IV): a metal of choice for innovative diagnostic methods”


10:00 - 10:30

Poster session & Coffee break


Session 3: Alternative biological models

10:30 - 11:00




Invited speaker: Rob Coppes, Professor, Department of Biomedical Sciences of Cells & Systems & Department of Radiation Oncology, University Medical Center Groningen & University of Groningen, Groningen, the Netherlands.  

 “The use of organoids in radiotherapy research; mechanisms, prediction and regeneration”


11:00 - 12:00

3 selected talks

  Maxime Dubail, Institut Curie, Inserm U1021-CNRS UMR 3347, University Paris-Saclay, PSL Research University, Centre Universitaire, Orsay, France.
“Development of an ex vivo assay enabling rapid quantification of radiotherapy induced toxicities in healthy lung“
  Estrella Passerat de la Chapelle, Space Biosciences Division, NASA Ames Research Center & Blue Marble Space Institute of Science & Nantes University, Nantes, France.
“Neurovascular responses to ionizing radiation in a human organ-on-a-chip model”
  Mathieu Chocry, ICO & Nantes Université, CNRS, US2B, UMR 6286, DNA-repair Group, Nantes, France.
“Induced radioresistance following communication of pericytes and vascular endothelial cells with glioblastoma cancer cells“
 12:00 - 14:00  Lunch  

Session 4: Artificial intelligence and Modeling


14:00 - 14:30




Invited speaker: Julien Bert, Research scientist, LaTIM, National Institute of Health & Clinical Sciences, Brest University, France.
“AI dose calculation: application in radiation and radionuclide therapies”



14:30 - 15:50

4 selected talks

  Marc Ryhiner, Department of Nuclear Medicine, Inselspital, University of Bern, Switzerland.
“Simulating quantitative PARPi radiosensitization of BRCA deficient cancer cells during radiopharmaceutical therapies”
  Eduardo Rios Sanchez, Creatis, Lyon & Siemens Healthcare SAS, Paris, France.
“68Ga-PSMA PET/CT Imaging Features with PSA Variation for Castration-Resistant Prostate Cancer Patients“
  Katerine Viviana Diaz Hernandez, Science Faculty, University of Zürich, Zürich, Switzerland.
“Fitting of novel analytical population tumor control probability model to NSCLC data“
  Paul Giraud, Radiation Oncology, Hôpital Pitié-Salpêtrière, Paris, France.
“External validation of a predictive model for severe malnutrition trained on a multicentric real-life cohort from UNITRAD”
15:30 - 16:10 Poster session & coffee break  
16:30 Social event  

Saturday October 7th

Session 5: Therapeutic combinations

 9:00 - 9:30





Invited speaker: Anna Mondino, Research scientist, Head of Lymphocyte Activation Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
“Prostate-confined radiotherapy to empower TCR/CAR T cells against primary and metastatic prostate adenocarcinoma”.


9:30 - 10:30

3 selected talks

  Charlotte Jacquet, CRCI2NA, UMR 1307 CNRS 6075 NU, Nantes, France.
“Radiobiology of alpha-particles: Immunogenicity of anti-tumor targeted-alpha therapy in mouse models“
  Hannah Bargh-Dawson, Institute of Cancer Research, London, United Kingdom.
“Evaluation of murine head and neck carcinoma models for determining response to ultrasound-stimulated microbubbles combined with radiotherapy”
  Juan Jiménez-Sánchez, Mathematical Oncology Laboratory (MOLAB), University of Castilla-La Mancha (UCLM), Ciudad Real, Spain.
“Chemo-radiotherapy optimization in gliomas: discrete models and virtual clinical trials“
10:30 - 10:50 Coffee break  
10:50 - 11:50
3 selected talks  
  Arianna Rinaldi, Nantes - Angers Cancer and Immunology Research Center, University of Angers, SFR ICAT, Angers, France.
“Polymer-lipid Hybrid Nanomedicines for siRNA Delivery Against Glioblastoma”
  Fábio A. C. Lopes, Physics Centre of Minho and Porto Universities (CF-UM-UP), University of Minho, Braga, Portugal.
“Development of multifunctional liposomes containing magnetic/gold nanoparticles for combination cancer therapies”
  Sarah Stelse-Masson, Institute for Advanced Biosciences, INSERM, CNRS & Synchrotron Radiation for Biomedicine, Université Grenoble Alpes, Grenoble, France.
“Scintillating nanoparticles to induce radiation dose-enhancement and X-PDT for pancreatic cancer”
12:00 Lunch & awards  
13:15 End of the workshop - Departure  

Other informations

Scientific sessions:

- Duration of selected talks is 15 minutes and 5 minutes for questions.


Poster session:

- The format of poster is A0 (vertical).

- Discussion around the posters will be possible during all coffee breaks. Posters should therefore be hanged for the entire duration of the workshop.